Adult-Gerontology Clinical Nurse Specialist (CNS) Practice Exam

Which of the following drugs would NOT be prescribed as a prophylactic treatment for a patient who suffers from migraine headaches?

1. Beta-blockers

2. Tricyclic antidepressants

3. Prednisone

4. Amitriptyline

The correct answer is: Prednisone

Prednisone is not typically prescribed as a prophylactic treatment for migraine headaches. Instead, it is a corticosteroid that is primarily used to manage acute inflammatory conditions or severe exacerbations of chronic illnesses, rather than serving as a preventive treatment for migraines. In contrast, beta-blockers and tricyclic antidepressants are commonly utilized for migraine prophylaxis. Beta-blockers help to prevent migraines by stabilizing blood vessels and reducing the frequency of migraine attacks. Tricyclic antidepressants, such as amitriptyline, are effective for migraine prevention due to their ability to modulate pain pathways and reduce the frequency of episodes. Amitriptyline, in particular, is often preferred due to its dual action in treating both depression and migraines, making it beneficial for patients who may exhibit comorbid conditions. Thus, while the other medications listed have well-established roles in the long-term prevention of migraines, prednisone does not fit within that framework, as it does not address the underlying mechanisms of migraine development.